The variations of gas hold-up, overall volumetric oxygen mass transfer coefficients and liquid circulation velocity in an internal loop reactor were investigated to manifest scale-up effect. The relationship between superficial gas velocity and gas hold-up were found as Ugr = 0.045 εr in the pilot-scale and Ugr = 0.056 εr in the bench-scale reactor. The overall volumetric oxygen mass transfer coefficient, K_La was slightly increased in the pilotscale than in the bench-scale reactor. Flow regime was changed from the bubble flow to the churn-turbulent flow when the superficial gas velocity reached to 3.5 - 4 ㎝/sec in the pilot-scale.