In order to investigate novel insect growth regulators (IGRs) from actinomycetes, 363 isolates of actinomycetes were tested for their IGR activities. Among them, Streptomyces sp. AN120537 showed the highest juvenile hormone antagonist (JHAN) activity and significant insecticidal activities against larvae of Aedes albopictus and Plutella xylostella. In addition, the dead larvae showed morphological deformities such as contraction of body segments or pigmentation of all body parts. Through liquid chromatography and bioassay-guided fractionation, 7 IGR compounds were identified from the crude hexane extract of AN120537. These results suggested that Streptomyces sp. AN120537 could be useful resources for development of eco-friendly insecticidal agents.

• Jong Hoon Kim(Department of Agricultural Biotechnology, Seoul National University)
• Jae Young Choi(Department of Agricultural Biotechnology, Seoul National University)
• Dong Hwan Park(Department of Agricultural Biotechnology, Seoul National University)
• Min Gu Park(Department of Agricultural Biotechnology, Seoul National University)
• Jun Young Kim(Department of Agricultural Biotechnology, Seoul National University)
• Minghui Wang(Department of Agricultural Biotechnology, Seoul National University)
• Hee Yeon Cho(Department of Agricultural Biotechnology, Seoul National University)
• Chang Jin Kim(Industrial Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB))
• Yeon Ho Je(Department of Agricultural Biotechnology, Seoul National University)