The Ryanodine Receptor in wild type Drosophila melanogaster has an amino acid substitution which is known to cause Chlorantraniliprole resistance in Pluteall xylostella. Even though we have reported that two Chlorantraniliprole resistant Drosophila strains have elevated total esterase activities, our report does not fully explain the significantly increased resistant ratios in two Chlorantraniliprole resistant Drosophila strains. Thus, we further analyzed alteration of reactive oxygen species and mitochondria activities in two Chlorantraniliprole resistant Drosophila strains. Our result suggested that Chlorantraniliprole resistance development in Drosophila requires alteration of various signal transduction pathways.

• A-Young Kim(Department of Bimedical Gerontology, Hallym University Garduate School/Ilsong Institute of Life Science, Hallym University)
• Phuong Nguyen(Department of Bimedical Gerontology, Hallym University Garduate School/Ilsong Institute of Life Science, Hallym University)
• In Hong Jeong(Department of Plant Protection, National Institute of Agricultural Sciences, Rural Development Administration)
• Young Ho Koh(Department of Plant Protection, National Institute of Agricultural Sciences, Rural Development Administration)