In this study, we evaluated the effect of branch (STB) and leave (STL) extracts from Sageretia thea on β-catenin level in human colorecal cancer cells, SW480 and lung cancer cells, A549. STB and STL dose-dependently suppressed the growth of SW480 and A549 cells. STB and STL decreased β-catenin level in both protein and mRNA level. MG132 decreased the downregulation of β-catenin protein level induced by STB and STL. However, the inhibition of GSK3β by LiCl or ROS scavenging by NAC did not block the reduction of β-catenin protein by STB and STL. Our results suggested that STB and STL may downregulate β-catenin protein level independent on GSK3β and ROS. Based on these findings, STB and STL may be a potential candidate for the development of chemopreventive or therapeutic agents for human colorectal cancer and lung cancer.

Abstract
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 References

• 김하나(국립안동대학교 생약자원학과) | Ha Na Kim (Department of Medicinal Plant Resources, Andong National University)
• 박광훈(국립산림과학원 산림약용자원연구소) | Gwang Hun Park (Forest Medicinal Resources Research Center, National Institute of Forest Science)
• 김정동(국립안동대학교 생약자원학과) | Jeong Dong Kim (Department of Medicinal Plant Resources, Andong National University)
• 박수빈(국립안동대학교 생약자원학과) | Su Bin Park (Department of Medicinal Plant Resources, Andong National University)
• 어현지(국립산림과학원 산림약용자원연구소) | Hyun Ji Eo (Forest Medicinal Resources Research Center, National Institute of Forest Science)
• 정진부(국립안동대학교 생약자원학과) | Jin Boo Jeong (Department of Medicinal Plant Resources, Andong National University) 교신저자