This study compares the differences in the gastrointestinal transit time between the conventional capsule endoscope and a minimized capsule endoscope model in normal dogs to verify whether the minimization of capsule endoscope can help relief retention in the gastrointestinal tract, especially in the pyloric passage. Three male beagles were used as the experimental group for which the minimized capsule endoscope model was orally administered and the control group consisted of three beagle dogs for which the conventional capsule endoscope was orally administered. Nine experiments were conducted with three experiments for each dog in each group. The results showed a significant difference in the gastric transit time (GTT) by the minimization of the capsule endoscope between the two groups (control group: 123.3 ± 80 min, experimental group: 63.3 ± 40.9 min, p=0.019). In contrast, the difference in the small bowel transit time (SBTT) by the minimization of the capsule endoscope between the two groups (control group: 86.6 ± 58.9 min, experimental group: 80 ± 33.5 min, p=0.863) was not significant. In this study, the capsule endoscopes reached the large intestine without retention in the small intestine in all subjects. The significant difference in the GTT between the control group using the conventional capsule endoscope and the experimental group using the minimized capsule endoscope model suggests that the smaller size of the capsule endoscope is helpful in resolving retention in the gastrointestinal tract, thus shorting the GTT.

Introduction
Materials and Methods
    Animals
    Capsule endoscope procedure
    Image analysis
    Statistical analysis
Results
    The rate of complete capsule endoscopy proceduresand GTT
    Comparison of GTT
    Comparison of SBTT
Discussion
References

• Dong-Hwan Lee(Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University)
• Joong-Hyun Song(Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University)
• DoHyeon Yu(Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University)
• Su-Jin An(Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University)
• Hee-Chun Lee(Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University)
• Young Joo Kim(College of Veterinary Medicine, Western University of Health Sciences)
• Donghyun Han(Section of Veterinary Research and Academic Consulting)
• Dong-In Jung(Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) Corresponding author