This research offers a concise retrospect on the South-South Coalition Strategy within multilateral trade negotiations of the GATT/WTO framework. The SSC strategy evolved in the postwar era, when the South integrated itself to demand for a New International Economic Order featured by fairness of outcome in international economic rules and activities. It then encountered an opponent trend of neo-liberalism, through which the South practically decided to sectoral exchange of economic interests with the North. From the new millennium onward, the South is learning to adopt a more issue-specific SSC strategy in trade negotiations. Although a question is arising for the future of SSC because of some emerging nations rising out from the traditional South group, a timely reflection from an evolutionary perspective would facilitate the understanding of the SSC strategy for weak countries to establish a fairer international economic order.