Probiotics improve the immune system. However, the effects of its lactic acid bacteria on atopic dermatitis relief and inflammation improvement is not fully understood. Recently, one of the probiotics, Lactobacillus helveticus HY7801 (HY7801), was found to have an anti-inflammatory effect. In this study, we investigated the effects of HY7801 on atopic dermatitis-induced animal models. After four weeks of oral administration, the group treated with HY7801 showed amelioration of the atopic dermatitis compared to the group receiving placebo. In the HY7801 treated group, the epidermal hyper-proliferation and collagen deposition were inhibited compared to the placebo group, and the secretion amount of the inflammatory factors, such as TNF-α, IL-4 were reduced. In conclusion, these results suggest that HY7801 acts as a functional probiotic via amelioration of the atopic dermatitis such as a decrease of epidermal hyper-proliferation, and collagen deposition and anti-inflammatory effects.

Abstract
서 론
재료 및 방법
    1. 실험동물 및 시약
    2. 실험동물 처치
    3. 육안평가
    4. 혈액을 이용한 cytokine 분석
    5. 조직검사
    6. 통계처리
결과 및 고찰
    1. 아토피 피부염 육안평가
    2. 표피두께 및 진피 콜라겐 밀도 변화
    3. 혈청 내 total IgE 함량 및 사이토카인 분비량 측정
요약 및 결론
References

• 박양규(㈜휴벳) | Yang-Gyu Park (HUVET Co., Ltd.)
• 조정휘(㈜휴벳) | Jeong-Hwi Cho (HUVET Co., Ltd.)
• 최진영(㈜휴벳) | Jinyoung Choi (HUVET Co., Ltd.)
• 김영필(㈜휴벳) | Youngpil Kim (HUVET Co., Ltd.)
• 유선정(㈜휴벳) | Seon-Jeong Yu (HUVET Co., Ltd.)
• 김옥진(원광대학교 동물자원개발연구센터) | Okjin Kim (Center for Animal Resources Development, Wonkwang University)
• 오홍근(㈜휴벳) | Hong-Geun Oh (HUVET Co., Ltd.) Corresponding author