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Anti-oxidative effect of baicalin in lipopolysaccharide-induced hippocampus damage KCI 등재
- 언어KOR
- URLhttps://db.koreascholar.com/Article/Detail/400931
pp.118-123
Baicalin is a flavonoid compound with many advantages, including anti-inflammatory agents and antioxidants. Lipopolysaccharide (LPS) is an endotoxin that induces neuronal damage through inflammatory response and oxidative stress reaction. This study was investigated the protective effects of baicalin on the oxidative stress and histopathological changes caused by LPS in hippocampus. Adult mice were divided into four groups; vehicle-treated, baicalin-treated, LPS-treated, and LPS and baicalin co-treated animals. Baicalin (10 mg/kg/day) and/or LPS (250 μg/kg/day) were intraperitoneally administered for seven consecutive days, and body weight was measured. Reactive oxygen species (ROS) level and lipid peroxidation level in the hippocampus were examined. Histopathological study was performed using hematoxylin and eosin staining manuals. LPS treatment decreased body weight and increased ROS and oxidative stress in the hippocampus. However, co-treatment with baicalin alleviated these changes caused by LPS. Severe histopathological changes were observed in the hippocampus of LPS-treated animals. Baicalin co-treatment attenuated the changes and preserved neuronal cells from LPS damage. These results showed that baicalin suppresses LPS-induced neuronal damage by alleviating oxidative stress in the hippocampus. Thus, this study demonstrated that baicalin exerts protective effects against LPS-induced oxidative stress in hippocampus.
서 론
재료 및 방법
실험동물 및 약물 투여
ROS 측정
지질 과산화(lipid peroxidation, LPO) 측정
Hematoxylin & eosin 염색
자료 분석
결 과
LPS와 baicalin 투여에 의한 체중의 변화
LPS와 baicalin 투여에 의한 ROS와 LPO의 변화
LPS와 baicalin 투여에 의한 해마조직의 조직병리학적 변화
고 찰
REFERENCES
