In this study, the failure characteristic of the center floor of a front-wheel drive vehicle was investigated according to material. UHSS, Al6061-T6, CFRP, and CFRP-Al were used as materials. As the analysis condition, a fixed support was applied to the rear surface of the center floor and a forced displacement of 2 mm/sec was applied to the front surface. As the result, when comparing with the equivalent stress and strain energy according to the material, it was found that UHSS, Al6061-T6, CFRP, and CFRP-Al were higher in the order. Also, when comparing with the equivalent strain due to the material, it was shown that the equivalent strain was high in the order of Al6061-T6, UHSS, CFRP and CFRP-Al. As for the damage characteristic of the center floor according to the material, it was found that the highest structural stability was obtained when UHSS was used. However, it was found that it was good to utilize Al6061-T6 in order to acquire the structural stability along with the structure with the lighter weight.