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창출(Atractylodes lancea) 추출물의 투여가 당뇨 유발 흰쥐의 혈당과 지질수준에 미치는 영향 KCI 등재

Effects of Atractylodes lancea on Plasma Glucose and Lipid Profile in Streptozotocin Induced Diabetic Rats

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한국식품영양학회지 (The Korean Journal of Food And Nutrition)
한국식품영양학회 (The Korean Society of Food and Nutrition)
초록

The purpose of this study was to examine the effects of Atractylodes lancea (A.l.) in a dose-dependent manner on lipid levels and plasma glucose in diabetic rats induced with streptozotocin (STZ). The Sprague-Dawley rats were randomly classified into five groups: normal, STZ-control and three experimental groups [A.l.-1, diabetic treated with ethanolic extract of A.l. (1 g/kg b.w.), A.l.-2, diabetic administered with ethanolic extract of A.l. (2 g/kg b.w.), and A.l.-3, diabetic administered with ethanolic extract of A.l. (3 g/kg b.w.)]. The normal and STZ-control group were fed an AIN-93 diet and the three experimental groups were administered with A.l. extract at doses of 1, 2, and 3 g/kg b.w./day, respectively, for 14 days. The plasma glucose levels in all the experimental groups were significantly lower than the STZ-control group after 14 days of treatment. The total cholesterol of the A.l.-3 and triglyceride levels, atherogenic index (AI) of all three experimental groups were significantly lower than the STZ-control group. The ALT and AST activities at A.l.-2, A.l.-3 were significantly lower than the STZ-control group. This result that demonstrate the administration of Atractylodes lancea can reduce hyperglycemia and hyperlipidemia risk in diabetic rats.

목차
Abstract
서 론
재료 및 방법
    1. 실험재료
    2. 실험동물 및 실험식이
    3. 당뇨 유발
    4. 시료수집 및 생화학적 분석
    5. 통계분석
결과 및 고찰
    1. 체중변화, 식이섭취량 및 식이효율
    2. 혈장 aminotransferase 활성도
    3. 헤마토크릿치
    4. 혈장 포도당 함량
    5. 혈장 지질 및 동맥경화지수
요약 및 결론
References
저자
  • 한혜경(덕성여자대학교 식품영양학과) | Hye Kyoung Han (Dept. of Food and Nutrition, College of Natural Science, Duksung Women’s University)
  • 최은영(경북전문대학교 식품영양과) | Eun Young Choi (Dept. of Food and Nutrition, KyungBuk College) Corresponding author