Nuclear power plant’s safety against seismic events is evaluated as risk values by probabilistic seismic safety assessment. The risk values vary by the seismic failure correlation between the structures, systems, and components (SSCs). However, most probabilistic seismic safety assessments idealized the seismic failure correlation between the SSCs as entirely dependent or independent. Such a consideration results in an inaccurate assessment result not reflecting real physical phenomenon. A nuclear power plant’s seismic risk should be calculated with the appropriate seismic failure correlation coefficient between the SSCs for a reasonable outcome. An accident scenario that has an enormous impact on a nuclear power plant’s seismic risk was selected. Moreover, the probabilistic seismic response analyses of a nuclear power plant were performed to derive appropriate seismic failure correlations between SSCs. Based on the analysis results, the seismic failure correlation coefficient between SSCs was derived, and the seismic fragility curve and core damage frequency of the loss of essential power event were calculated. Results were compared with the seismic fragility and core damage frequency of assuming the seismic failure correlations between SSCs were independent and entirely dependent.