A progressive muscle atrophy is strongly associated with aging, resulting in lower quality of life in elderly individuals. This study was conducted to determine relative hemoglobin (Hb) concentrations in the rabbit model of the sciatic nerve transection injury using non-invasive diffuse optical spectroscopy (DOS). From the 2nd week to the end of the experiment after sciatic nerve injury, a total muscle mass in nerve injured-group (NI group) significantly reduced compared with that in the normal group (p<0.001). During the capillary occlusion after nerve injury, the deoxy-hemoglobin (Hb-R) concentration in NI group significantly increased compared to that in the normal group at the 2nd and 3rd week after sciatic nerve injury (p<0.05). During the capillary release after nerve injury, the oxy-hemoglobin (Hb-O2) concentration in NI group significantly decreased at the 1st and 3rd week, and Hb-R significantly increased at 2nd week, compared to those in the normal group (p<0.05). Histological changes in the gastrocnemius muscle of NI group observed that clear fat filled spaces at the periphery of muscle fibers and angular fibers. From the results of this study, non-invasive DOS could be used to measure changes of Hb concentrations in muscles.

서 론
재료 및 방법
    실험동물
    좌골 신경 절단
    근적외선 DOS
    Hb 농도 변화 분석법
    적절성 실험
    Hb-O2와 Hb-R의 변화 측정
    근육량 변화 측정
    조직학적 변화
    통계 처리
결 과
    근육량의 변화
    Hb-O2와 Hb-R의 농도 변화
    조직학적 소견
고 찰
감사의 글
REFERENCES

• Yikeun Kim(Pukyong National University, Innovative Biomedical Technology Research Center) Co-Author
• Chang Su Kim(Department of Orthopedic Surgery, College of Medicine, Kosin University) Co-Author
• Hu-Jang Lee(Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) Corresponding Author
• Yeh-Chan Ahn(Pukyong National University, Innovative Biomedical Technology Research Center) Corresponding Author
• Eun-Kee Park(Department of Medical Humanities and Social Medicine, College of Medicine, Kosin University) Corresponding Author