A tilted tall building is actively constructed as landmark structures around world to date. Because lateral displacement responses of a tilted tall building occurs even by its self-weight, reduction of seismic responses is very important to ensure structural safety. In this study, a smart tuned mass damper (STMD) was applied to the example tilted tall building and its seismic response control performance was investigated. The STMD was composed of magnetorheological (MR) damper and it was installed on the top floor of the example building. Control performance of the STMD mainly depends on the control algorithn. Fuzzy logic controller (FLC) was selected as a control algorithm for the STMD. Because composing fuzzy rules and tuning membership functions of FLC are difficult task, evolutionary optimization algorithm (EOA) was used to develop the FLC. After numerical simulations, it has been seen that the STMD controlled by the EOA-optimized FLC can effectively reduce seismic responses fo the tilted tall building.