Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the colon and rectum with intervals of acute exacerbation. Its etiology remains unknown, although recent studies suggest that pro-inflammatory cytokines initiate the inflammatory responses. In this study, we investigated the ameliorative effects of YB-21 (new product containining Lactobacillus plantarum, Barley Bran and Nymphaeaceae) in a dextran sulfate sodium (DSS)-induced colitis in mice. The experimental groups were divided into 6 groups (n = 10) of ICR mice: normal control(NC), DSS-treated(PC, positive control), DSS+latic-L-treated (3×107CFU/ml), DSS+latic-M-treated (3×109CFU/ml), DSS+latic-H-treated (3×1011CFU/ml), and DSS+YB-21-treated. Histological examinations indicated that YB-21 suppressed edema, mucosal damage, and the loss of crypts induced by DSS. Moreover, YB-21 reduced serum level expressions of, tumor necrosis factor-α (TNF-α). These results suggest that YB-21 has an anti-colitic effect by the suppression of intestinal inflammatory responses in DSS-induced colitis in mice.

Abstract
서 론
재료 및 방법
    재료 및 추출
    유산균
    동물실험군 구성 및 DSS를 이용한 장염 유발
    혈장 및 장기채취
    TNF-α 측정
    병리조직학적 검사
    통 계
결 과
    대장 길이와 무게 소견
    TNF-α 분석
    조직병리학적 평가
고 찰
REFERENCES

• Hyun-A Lee(Center for Animal Resources Development, WonkwangUniversity)
• Sunju So(Center for Animal Resources Development, WonkwangUniversity)
• Injeong Choi(Youngin Bio Co., Ltd)
• Somi Kang(Youngin Bio Co., Ltd)
• OKjin Kim(Center for Animal Resources Development, WonkwangUniversity) Corresponding Author