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염산/에탄올로 유도된 급성 위염 동물모델에서 십자화과 생즙 발효물의 위점막 보호 효과 KCI 등재

Protective Effect of Fermented Brassica Puree on HCl/Ethanol-Induced Acute Gastritis via Prevention of Gastric Mucosal Injury

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  • URLhttps://db.koreascholar.com/Article/Detail/410409
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한국식품영양학회지 (The Korean Journal of Food And Nutrition)
한국식품영양학회 (The Korean Society of Food and Nutrition)
초록

In recent years, there has been an increase in the morbidity of gastritis in Korea due to lifestyle factors mostly changes in eating habits and stress. Gastritis is more likely to progress to gastric cancer, and therefore it is important to prevent and manage gastritis through lifestyle adjustment and treatment at an early stage. In this study, cabbage, which was found to be effective in gastritis, was mixed and fermented with other crucifer plants such as kale and broccoli to evaluate the overall efficacy of fermented brassica puree on alcoholic acute gastritis. Based on our results, fermented brassica puree alleviated gastric injury induced by 150 mM HCl/60% ethanol. In addition, it was confirmed that PGE2, a gastric mucosal protective factor, was increased, and other positive effects such as an increase of MUC1 and regulation of PKC were observed. The results of this study suggest that fermented brassica puree can relieve acute alcoholic gastritis by regulating PGE and the expression of MUC1, a gene related to mucus secretion, and activating PKC, which is related to mucosal cell activity.

목차
Abstract
서 론
재료 및 방법
    1. 실험 재료
    2. 실험동물 및 처지
    3. 혈액 및 조직 시료 채취
    4. 조직 관찰
    5. 혈액을 이용한 Prostaglandin E2 분석
    6. PCR을 이용한 조직 내 mRNA 발현 분석
    7. Western blot를 이용한 조직 내 단백질 발현 분석
    8. 통계처리
결과 및 고찰
    1. 십자화과 생즙 발효물이 알코올성 급성위염에 의한 위점막출혈에 미치는 효과
    2. 십자화과 생즙 발효물이 위 조직 병변 개선에 미치는효과
    3. 십자화과 생즙 발효물이 위 점막 보호 인자들에 미치는 영향
요약 및 결론
References
저자
  • 박양규(㈜휴벳) | Yang-Gyu Park (HUVET Co., Ltd.)
  • 조정휘(㈜휴벳) | Jeong-Hwi Cho (HUVET Co., Ltd.)
  • 최진영(㈜휴벳) | Jinyoung Choi (HUVET Co., Ltd.)
  • 김영필(㈜휴벳) | Youngpil Kim (HUVET Co., Ltd.)
  • 이상엽(㈜휴벳) | Sang-yeob Lee (HUVET Co., Ltd.)
  • 박주헌(㈜풀무원 풀무원기술원) | Ju-Hun Park (Corporate Technology Office, Pulmuone Co., Ltd.)
  • 오홍근(㈜휴벳) | Hong-Geun Oh (HUVET Co., Ltd.) Corresponding author