논문 상세보기
pp.71-78
매실 에탄올추출물이 알코올투여로 유발된 횐쥐의 간손상에 미치는 영향을 알아보기 위하여 실험동물을 정상군, 매실 에탄올추출물 200 mg/kg 투여군, 알코올투여군(35% ethanol 10 mL/kg, b.w./day), 알코올 및 매실 에탄올추출물 200 mg/kg 병합투여군과 알코올 및 매실 에탄올추출물 400 mg/kg 병합투여군의 5군으로 나누어 6주간 사육하였고, 체중증가율 및 식이효율, 혈청중 ALT와 AST활성, 간손상 억제 효과를
To investigate the antioxidative effects of Prunus mume ethanol extract on the ethanol-induced hepatotoxicity in rat liver, Sprague-Dawley rats weighing 120∼160 g were divided into 5 groups; normal group(NOR), Prunus mume ethanol extract 200mg/kg treated group(PME), ethanol(10 mL/kg, 35％) treated group(ETH), Prunus mume ethanol extract 200 mg/kg and ethanol treated group (PML) and Prunus mume ethanol extract 400 mg/kg, and ethanol treated group(PMF), respectively. The antioxidative activity in vitro was reduced in order of EtOAC＞n-hexane＞water＞ chloroform fraction. The growth rate and feed efficiency ratio decreased by ethanol administration were gradually increased to the adjacent level of NOR by administering Prunus mume ethanol extract. It was observed that activities of catalase, superoxide dismutase(SOD), xanthine oxidase and glutathione peroxidase(GSH-Px) of liver and alanine aminotransferase(ALT) and asparate aminotransferase(AST) of serum were elevated by ethanol administration. Besides, Prunus mume ethanol extract markedly decreased elevated activites of catalase, GSH-Px, ALT and AST, except in activites of SOD and xanthine oxidase compared to ETH. Also, the depleted content of GSH by ethanol was increased similar to NOR level by administering Prunus mume ethanol extract. These results suggested that Prunus mume ethanol extract has a possible protective effect on the ethanol-induced hepatotoxicity in rat liver.
