This review summarizes the recent progress in iron-oxide-based heat generators. Cancer treatment using magnetic nanoparticles as a heat generator, termed magnetic fluid hyperthermia, is a promising noninvasive approach that has gained significant interest. Most previous studies on improving the hyperthermia effect have focused on the construction of dopant-containing iron oxides. However, their applications in a clinical application can be limited due to extra dopants, and pure iron oxide is the only inorganic material approved by the Food and Drug Administration (FDA). Several factors that influence the heat generation capability of iron-oxide-based nanoparticles are summarized by reviewing recent studies on hyperthermia agents. Thus, our paper will provide the guideline for developing pure iron oxide-based heat generators with high heat dissipation capabilities.

Abstract
1. 서 론
2. 자성 발열체의 발열 원리
3. 자성 발열체의 발열 효과에 영향을 끼치는요소들
    3.1. 발열체의 결정종류
    3.2. 발열체의 크기
    3.3 발열체의 형태
    3.4. 표면 코팅
    3.5. 발열체의 군집 형성(입자간의 상호 작용)
    3.6. 나노 복합체 형성
4. 응용 분야
    4.1. 온열 치료
    4.2. 선택적 약물 전달
5. 결 론
References

• 최진실(한밭대학교 화학생명공학과) | Jin-sil Choi (Department of Chemical and Biological Engineering, Hanbat National University) Corresponding Author