In Nepal, about 73% of the vegetable production area is estimated to be covered by hybrid varieties. Most of the hybrid seeds in vegetable crops are imported from abroad. Considering the demand for hybrid vegetable varieties, the National Horticulture Research Centre (NHRC), Khumaltar, Lalitpur has started hybrid breeding of vegetables using a conventional approach since the fiscal year 2003/04. With this effort, the tomato hybrid ‘Srijana’ was developed and registered in 2010. This variety was estimated to cover about 35% of the total tomato cultivated area. Two tomato hybrids, namely ‘Khumal Hybrid Tomato-2 (HRA14 × HRD7) and ‘Khumal Hybrid Tomato-3’ (HRA20 × HRD2), showed good performance and were released in the National Seed Board in 2021. It was found that the heterosis for the yield was 87% in ‘Khumal Hybrid Tomato-2’ and 95% in ‘Khumal Hybrid Tomato-3’ with a potential yield of 70 MT/ha and 60 MT/ha, respectively, under open field conditions. Similarly, a comparative study of 7 tomato hybrids at different research stations was carried out and it showed that F1 (HRA13 × HRD7) could be a potential hybrid for the western region with a potential productivity of 116.8 MT/ha under a protected cultivation system. Hybrid breeding of cucumber was also initiated in the fiscal year 2007/08. A total of 12 crosses in cucumber were performed and two hybrids F1 (HRDCUC004 x RDCUC001), 107 MT/ha and F1 (HRDCUC009 × HRDCUC003) 150 MT/ha were found promising. Hybrid breeding in brinjal, hot pepper and bitter gourd has also been started. Furthermore, key problems and way forward to strengthen hybrid vegetable breeding in Nepal were also discussed.