논문 상세보기
pp.496-500
홍경천(Rhodiola dumulosa)을 기능성 식품소재로 개발하기 위하여 홍경천(뿌리)을 80% 메탄올로 열수 추출하여 용매 분획한 후 이들에 대한 항산화, 암세포 성장 억제 및 대식세포의 면역활성 등과 같은 기능성을 조사하였다. 홍경천 메탄올 추출물의 헥산, 에틸 아세테이트, 부탄올, 메탄올 및 물 분획물의 수소공여능은 100 의 농도에서 각각 28.30, 53.21, 35.48, 42.64 및 21.14% 로서 에틸아세테이트 분획물이 가장
To develop functional food material using Rhodiola dumulosa(RD), the biological activities such as antioxidation, antiproliferation in the cancer cells and immuno-activity in macrophage cells were investigated with hexane, ethylacetate, n-butanol, methanol and water fractions of RD 80% methanol extract. Hydrogen-donating activities of hexane, ethyl acetate, n-butanol, methanol and water fraction were 28.30, 53.21, 35.48, 42.64 and 21.14%, respectively, at a concentration of 100 , and the activity of ethyl acetate fraction was similar to as that of BHT. After treated for 48 hrs, the ethyl acetate fraction decreased the proliferation of the A549 and SW480 cells in a dose-dependent manner at concentration of 10, 50, and 100 , the activities were higher than other fractions. Morphology of cells treated with the ethyl acetate fraction for 48 hr at 100 was distorted with shrank cell mass, and the cell number was lower than that of control cells the macrophage cells treated. The methanol fraction was significantly induced NO production compared with untreated control cells at above 10 concentration. These results indicate that RD would be used the functional food material.
