Osteoarthritis is a degenerative change in the joint that causes damage to the articular cartilage, resulting in overexpression of inflammatory cytokine in the damaged chondrocytes, which leads to damage to the articular cartilage and is completely treated with antibiotics. We recovered the damage to the articular cartilage caused by osteoarthritis and investigated the effect of a low-molecular-weight collagen-based functional material without side effects. In this study, we investigated the ameliorative effects of YB in a monosodium idoacetate(MIA)-induced osteoarthritis rats. The experimental groups were divided with 5groups (n = 12) of SD rat: normal control(NC), MIA, MIA+L. plantarum (3×1011 CFU/ml), MIA+collagen and MIA+YB-21. Histological examinations indicated that YB-21 cartilage structure change, cartilage cell damage, and the loss of proteoglycan induced by MIA. Moreover, YB-21 reduced serum level expressions of, tumor necrosis factor-α(TNF-α), Interleukin6(IL-6), Interleukin1β(IL-1 β), Matrix metalloproteinase-9(MMP-9), Tissue inhibitor of metalloproteinases-1(TIMP-1). These results suggest that YB has a positive effect on osteoarthritis by restoring joint cartilage and anti-inflammatory effects due to the reaction of osteoarthritis in the MIA-induced rat.

• Sunju So(Center for Animal Resources Development, Wonkwang University, Iksan 54538, Republic of Korea)
• Hyung-Suk Lee(Division of Companion Animal Science, Woosong College, Daejeon 34518, Republic of Korea)
• Hyun-A Lee(Center for Animal Resources Development, Wonkwang University, Iksan 54538, Republic of Korea, Department of Companion Animal Industry, Wonkwang University, Iksan 54538, Republic of Korea) Corresponding author