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pp.760-768
EPS 생성 유산균인 Leu. kimchii GJ2의 생리활성 효능을 구명하기 위하여 고콜레스테롤식이를 급여한 흰쥐에게 Leu. kimchii GJ2 투여로 고지혈증 개선효과를 조사하였다. 체중증가율, 식이섭취량 및 식이효율은 실험군 간의 차이가 없었으나, 체중당 간의 무게는 고콜레스테롤식이군 (HCD)이 다른 실험군들에 비하여 유의하게 증가되었다. 고콜레스테롤식이 급여로 증가된 혈청 중 GOT 및 ALP 활성은 Leu. kimchii GJ2 투
The present study investigated the effect of Leuconostoc kimchii GJ2 (Leu. kimchii GJ2), an exopolysaccharide-producing lactic acid bacterium isolated from kimchi, on serum and liver lipid metabolism in rats fed a high-cholesterol diet. Male Sprague-Dawley rats were divided into four groups: a normal diet group (ND), a high-cholesterol diet group (HCD), a high-cholesterol diet and 200 mg/kg Leu. kimchii GJ2-administered group (HCD-LKL), and a high-cholesterol diet and 400 mg/kg Leu. kimchii GJ2-administered group (HCD-LKH). No between-group differences were found in body weight gain, food intake, or food efficiency ratio. The serum GOT and ALP activities that were elevated by the high-cholesterol diet were significantly decreased after Leu. kimchii GJ2 administration. Serum HDL-cholesterol level was markedly increased in the Leu. kimchii GJ2-administered groups, whereas the serum total cholesterol and LDL-cholesterol levels were lower in the Leu. kimchii GJ2-administered animals. Liver levels of total cholesterol and triglyceride were also markedly lower in the Leu. kimchii GJ2-administered groups. In addition, increased activities of HR-LPL and TE-LPL in adipose tissue, caused by the high-cholesterol diet, fell to normal after administration of Leu. kimchii GJ2, in a dose-dependant manner. These results suggest that Leu. kimchii GJ2 isolated from kimchi exerts an antiatherosclerotic effect by reducing serum and liver cholesterol levels.
