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악골 근처의 표재성 엡스타인-바 바이러스 관련 림프증식성 질환의 예후: 2건의 증례보고 및 문헌고찰 KCI 등재
Prognosis of Superficial Epstein-Barr Virus-associated Lymphoproliferative Disorders Near the Gnathic Bone: Two Case Reports and Literature Review
pp.95-103
EBV-positive mucocutaneous ulcer (EBVMCU) is an indolent, superficial lymphoproliferative disorder that occurs in either iatrogenic or age-associated immunocompromised patients with latent Epstein-Barr virus (EBV) infection. Although EBVMCU is histologically similar with other lymphoproliferative disorders, such as EBV-positive diffuse large B cell lymphoma, the diseases are classified as distinct entities by the World Health Organization with different clinical manifestations, prognosis, and genetic profiles. EBVMCU commonly shows spontaneous regression by conservative management, reduction or cessation of immunosuppressive treatment, but local progression is possible. Complete remission of disease can be achieved with combination of surgical resection, chemotherapy and local radiation therapy. Herein, we report 2 cases of oral superficial lymphoproliferative disorders arising adjacent to the gnathic bone with striking differences in prognosis and bone involvement. One of the cases induced extensive osteomyelitis in the underlying bone. Furthermore, we discussed the differential diagnosis of EBVMCU and reviewed the former literature.
Ⅰ. INTRODUCTION
Ⅱ. CASE REPORT
1. Case 1
2. Case 2
Ⅲ. DISCUSSION
Ⅳ. CONCLUSION
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