Mucoepidermoid carcinoma (MEC) is the most prevalent malignant tumor originating from the salivary gland. The gradation of MEC is determined histologically based on cellular composition, with high-grade MEC presenting with distinct characteristics and clinical implications. A 56-year-old male presented with a 3-month history of right facial swelling and a recent onset of pain. A subsequent biopsy confirmed a malignant epithelial tumor, with further imaging assisting in determining the surgical approach. Comprehensive surgery, involving the removal of the right submandibular gland and reconstructive procedures, was undertaken. Histopathological evaluation post-surgery confirmed a high-grade MEC. The differentiation between inflammatory conditions and neoplastic lesions in the orofacial region can be challenging. The gradation of MEC is important in guiding therapeutic decisions. Among various classification systems, the Brandwein system offers detailed histopathological criteria that correlate reliably with clinical features. High-grade MECs, although less frequent, are aggressive and have a lower 5-year survival rate. Accurate histopathological diagnosis is crucial in devising an effective treatment plan. The presented case underlines the importance of a meticulous yet periodic follow-up, considering the aggressive nature of high-grade MECs.

According to the classification of World Health Organization, primary adenocarcinomas of the sinonasal tract can be initially classified as salivary and non-salivary types. The latter are further divided into intestinal and non-intestinal types. Sinonasal intestinal-type adenocarcinoma(ITAC) is rare adenocarcinoma subtype, which is closely occupational exposure to hardwood dusts, leather. In this study, we present a case of ITAC in a 68-year-old man. We successfully treated with wide excision and soft tissue reconstruction with free anterolateral thigh flap.

EBV-positive mucocutaneous ulcer (EBVMCU) is an indolent, superficial lymphoproliferative disorder that occurs in either iatrogenic or age-associated immunocompromised patients with latent Epstein-Barr virus (EBV) infection. Although EBVMCU is histologically similar with other lymphoproliferative disorders, such as EBV-positive diffuse large B cell lymphoma, the diseases are classified as distinct entities by the World Health Organization with different clinical manifestations, prognosis, and genetic profiles. EBVMCU commonly shows spontaneous regression by conservative management, reduction or cessation of immunosuppressive treatment, but local progression is possible. Complete remission of disease can be achieved with combination of surgical resection, chemotherapy and local radiation therapy. Herein, we report 2 cases of oral superficial lymphoproliferative disorders arising adjacent to the gnathic bone with striking differences in prognosis and bone involvement. One of the cases induced extensive osteomyelitis in the underlying bone. Furthermore, we discussed the differential diagnosis of EBVMCU and reviewed the former literature.

Plunging ranula is a mucous retention cyst with extension below to the mylohyoid muscle. It can occur by an extravasation of saliva from the salivary gland due to trauma or obstruction of the duct. Fluid from the obstructed gland penetrate through the defect of mylohyoid muscle or through the posterior edge of mylohyoid muscle, and spreading to the cervical area. The “tail sign” has been widely reported as pathognomonic for their diagnosis. It indicates the communication between the collapsed sublingual and submandibular space over the posterior edge of the mylohyoid muscle. In this case, in addition to simple ranula in the right floor of mouth, MRI findings showed homogeneous contrast enhancement in front of the right cervical carotid artery and in the deep part of sternocleidomastoid muscle, but tail sign was not observed. Therefore it was clinically diagnosed as a branchial cleft cyst and was removed through surgical procedure. As a result of the final pathologic biopsy, the lesion, which has been suggested to be simple ranula in the floor of mouth, was diagnosed as reactive pyogenic granuloma, and the cervical lesion was diagnosed as a plunging ranula. This is a case report in which these two lesions are decided to have been separated from one before surgery. This report indicate that plunging ranula can be observed without tail sign and how to make an accurate diagnosis of plunging ranula by reporting misdiagnosis case.

Mucormycosis is an aggressive opportunistic fungal infection that can be found in the oral cavity. The fungus usually affects the immunocompromised patients and tends to invade and block blood vessels, resulting in significant tissue necrosis and invasive mucormycosis. However, a non-invasive form of mucormycosis is mostly asymptomatic and found accidentally in the immunocompetent normal hosts, manifested by localized overgrowth of the fungus. Here, we report a rare case of asymptomatic non-invasive mucormycosis of the mandible that was incidentally diagnosed in wide resection specimen of liver transplant patient who had previously underwent surgery of excision and simultaneous alloplastic bone graft due to mandibular ameloblastoma. Histopathological examination of the specimen revealed that there was neither vasculitis nor tissue necrosis, but numerous fungal hyphae were located only within the alloplastic graft materials in decalcified tissue sections. Awareness of the possibility of life-threatening mucormycosis in immunocompromised patients should be emphasized because it can be inactive or reactivated depending on the immune state of patients.

Lingual cyst is a clinical term indicating a cyst occurring within the tongue. Various disease may clinically present as a lingual cyst, such as foregut cyst, dermoid cyst, thyroglossal duct cyst, salivary duct cyst, hemangioma and ranula. In general, lingual cysts are asymptomatic but may cause airway obstruction, feeding or swallowing problems. Most of these lesions can be simply treated by surgical excision with good postoperative healing and low recurrence rate. Apart from that, histopathological diagnosis of the lesion is important because it means the origin of the lesion. Thus it is important to rule out several origins of lingual cyst histopathologically, because it might be related with adjacent anatomical structure or may indicate cysts on other sites. Herein, we reported a case of lingual cyst with columnar epithelium at the ventral tongue of a 46-year old man and reviewed the clinical and histopathological considerations required for further classification in lingual cysts.

Odontogenic keratocyst (OKC) is aggressive compared to other odontogenic cysts, but its malignant transformation is extremely rare. Odontogenic carcinoma may arise from an odontogenic cyst such as OKC. Here in, we introduce a case of odontogenic carcinoma assumed to have arisen from a preexisting OKC. Abnormal clinical and radiologic features seen in a previous or existing cyst may be warning signs of malignant transformation.

조직 플라스미노겐 활성제(Tissu-type plasminogen activator; tPA)는 혈전 용해제로 이용되고 있으며, 주로 심근경색증과 같은 급성 혈전후성 허혈증 등을 치료하는 데 유용하다. 본 연구에서는 혈관 질환 치료제를 생산하기 위하여 체세포 복제를 이용한 htPA 를 발현하는 형질전환 복제 돼지를 생산하였다. 형질전환 복제란 8,026 개를 25 두의 대리모에(321 개/1 두) 이식하였으며, 25 두 중 6 두의(24%) 대리모가 자연분만으로 19 두의(3.2 두/1 두) 산자를 생산하였다. 19 두 중 1 두가(1/19 두, 5.3%) 생존 중에 있으며, 8 두는 사산 개체였고(8/19 두, 42.1%), 10 두는 출생 후 2-3 일내에 폐사하였다(10/19 두, 52.6%). 폐사 개체들은 혀 기형, 구개열 등 안면기형이 관찰되었으며, 이와 함께 관절 혹은 발굽의 모양이 비정상적이라는 것을 확인하였다. 또한, 폐사개체들은 모두 하나 이상의 문제점을 동시에 가지고 있음을 확인하였다. 따라서, 이러한 문제점들이 형질전환에 의한 것인지, 아니면 복제에 의한 것인지를 규명하기 위해 연구를 더 진행해야 할 것으로 사료된다.조직 플라스미노겐 활성제(Tissu-type plasminogen activator; tPA)는 혈전 용해제로 이용되고 있으며, 주로 심근경색증과 같은 급성 혈전후성 허혈증 등을 치료하는 데 유용하다. 본 연구에서는 혈관 질환 치료제를 생산하기 위하여 체세포 복제를 이용한 htPA 를 발현하는 형질전환 복제 돼지를 생산하였다. 형질전환 복제란 8,026 개를 25 두의 대리모에(321 개/1 두) 이식하였으며, 25 두 중 6 두의(24%) 대리모가 자연분만으로 19 두의(3.2 두/1 두) 산자를 생산하였다. 19 두 중 1 두가(1/19 두, 5.3%) 생존 중에 있으며, 8 두는 사산 개체였고(8/19 두, 42.1%), 10 두는 출생 후 2-3 일내에 폐사하였다(10/19 두, 52.6%). 폐사 개체들은 혀 기형, 구개열 등 안면기형이 관찰되었으며, 이와 함께 관절 혹은 발굽의 모양이 비정상적이라는 것을 확인하였다. 또한, 폐사 개체들은 모두 하나 이상의 문제점을 동시에 가지고 있음을 확인하였다. 따라서, 이러한 문제점들이 형질전환에 의한 것인지, 아니면 복제에 의한 것인지를 규명하기 위해 연구를 더 진행해야 할 것으로 사료된다.

Cervical neck dissection is a frequent technique during treatment for oral squamous cell carcinoma (SCC). Occasionally, specimens harvested as cervical lymph nodes reveal thyroid tissue and need differentiation with metastatic thyroid cancer and ectopic thyroid tissue. Here, we report a case of an ectopic thyroid tissue with lymphocytic thyroiditis mimicking thyroid cancer metastasis at the cervical lymph node.

Ameloblastic fibrosarcoma (AFS) is an extremely rare malignant odontogenic tumor characterized with benign ameloblastic cells islands and malignant mesenchymal component. While two-thirds of AFS seem to arise de novo, but one-third develops from recurrent ameloblastic fibroma (AF) or ameloblastic fibro-odontomas (AFO). Pathological distinction of malignant transformation is essential for appropriate treatment. The patient was a 28 years old man. Since the primary tumor was excised, the mass recurred 2 years later. The recurrent tumor was diagnosed as AFS. Chief complaint was pain in the right mandible. Computer tomography finding revealed multilocular intrabony lesion with radiopaque substance in the primary lesion. In the recurrent lesion cortical bone destruction was found. Microscopically, both the primary and recurrent lesions showed benign ameloblastic follicles with myxoid or highly cellular mesenchymal proliferation. The histological difference between primary and recurrent lesions were that foci of dental hard tissue composed of enamel and dentin were found only in the primary lesion, whereas nuclear pleomorphism was aggrevated in the recurrent lesion. The histological criteria determining malignancy were discussed.

The conventional shifting map is developed to enhance the driving performance and fuel economy. According to the driver’s pedaling of accelerator, TCU controls gear ratio in view point of economy or driving performance. In this paper, various reverse engineering is applied to the driving test results of heavy duty AMT vehicle. With the test results, the performance of propulsion source is estimated and basic performance of vehicle is analized. Also the method to derive the shifting schedule according to power or fuel efficient, is developed and compared with the actual shifting map, and various shifting states is estimated. The developed numerical analysis model will be a stepping stone for the shift pattern development and various shift control research

Primary oral squamous cell carcinoma (OSCC) associated with dental osseointegrated implants is very rare. We experienced two patients who had received dental implant surgery before they were diagnosed with OSCC. We report these cases to emphasize the importance of differential diagnosis of malignant lesions associated with dental implants. Additionally, we also suggest that bone graft materials around implants can serve as a potential inducer of invasiveness in cancer cells.

본 연구는 기업의 제품혁신 과정에서 기술협력 활동과 전유성의 확보가 제품혁신성과에 어떠한 영향을 미치는지 살펴보았다. 추가적으로 협력활동과 전유성의 상호작용 효과 (전유성의 조절효과)에 대하여 분석하였다. 과학기술연구원에서 조사한 2010년 한국 제조업의 기술혁신조사 자료를 이용한 실증분석 결과 고객과의 협력활동과 계열사와의 협력활동이 제품혁신에 긍정적인 영향을 미치는 것으로 나타났다. 또한, 전유성의 그 자체로 제품혁신에 긍정적인 영향을 줄 뿐만 아니라 고객과의 협력활동이 제품혁신에 주는 긍정적인 영향을 배가시키는, 다시 말해 제품혁신에서 전유성의 중요성이 확인되었다. 이러한 연구 결과를 바탕으로 제품혁신 성과를 높이기 위한 전략적 시사점을 도출하였다. 제품혁신에서는 기술협력활동뿐만 아니라 전유성의 확보가 혁신성과를 결정하는 중요한 요인이기에 기업에서는 기술협력활동의 활성화 및 기술의 전유성 확보에 힘써야 할 것이며 이러한 전유성의 확보를 위한 기술보호 수단의 전략적 활용에 대한 통찰이 필요하다.

건설폐기물의 재활용방법 중 하나는 폐콘크리트 재생골재를 도로포장재료로 활용하는 것이다. 하지만 재생골재에 대한 많은 연구와 기술개발에도 불구하고 생산공정에 포함된 이물질 때문에 실제 도로포장재료로의 적용은 미비한 실정이다. 본 연구에서는 재생골재내에 포함된 이물질의 특성에 따라 무기이물질과 유기이물질로 구분하였으며 , 각 이물질이 포장 공용성에 미치는 영향을 제시하였다. 또한 재생골재내에 포함된 무기이물질 함유량과 압축강도와의 관계, 유기이물질 함유량과 수정 CBR과의 상관관계를 통하여 도로포장층인 린콘크리트 기층과 보조기층에 적용 가능한 이물질 함량기준을 제시하였다. 린콘크리트 기층에는 무기이물질 함유량 질량비 10% 이하, 입상재료 보조기층에는 유기이물질 함유량 부피비 2% 이하일 때 재생골재를 포장에 적용 가능한 것으로 나타났다.

This paper describes the NC simulator system for Wire-cut electrodischarge machining. Electrodischarge Wire-cut machining is applicable to all materials including metals, alloys, and most carbides. Although CAM system generate the NC code considering electrodischarge conditions, incorrect Wire-cut tool path bring about fatal results. The simplest way of simulating a EDM process is to display the trajectory of Wire-cutter location by line segments. With this kind of simulation, the programmer can get a general idea about whether the wire is moving as planned but cannot locate gouging or excess material because only the wire location will be seen, not the changes in the workpiece as it is machined. The ideal way of simulating the EDM process is to display the solid model of the workpiece as it is machined. Therefore we propose the ideal NC simulator system for Wire-cut EDM.

This paper describes the NC simulator system for Wire-cut electrodischarge machining. Electrodischarge Wire-cut machining is applicable to all materials including metals, alloys, and most carbides. Although CAM system generate the NC code considering electrodischarge conditions, incorrect Wire-cut tool path bring about fatal results. The simplest way of simulating a EDM process is to display the trajectory of Wire-cutter location by line segments. With this kind of simulation, the programmer can get a general idea about whether the wire is moving as planned but cannot locate gouging or excess material because only the wire location will be seen, not the changes in the workpiece as it is machined. The ideal way of simulating the EDM process is to display the solid model of the workpiece as it is machined. Therefore we propose the ideal NC simulator system for Wire-cut EDM.