논문 상세보기
산양삼 잎으로부터 Pancreatic lipase 저해 활성물질의 분리 KCI 등재 SCOPUS
Pancreatic Lipase Inhibitors Isolated from the Leaves of Cultivated Mountain Ginseng (Panax ginseng)
- 언어KOR
- URLhttps://db.koreascholar.com/Article/Detail/41863
pp.727-732
신선한 산양삼 잎을 EtOH로 침지 추출하여 얻어진 추출물을 n-hexane, EtOAc, n-BuOH 로 용매 분획하였다. 이중 pancreatic lipase 저해활성이 상대적으로 높은 EtOAc 분획에 대해 silica 및 column chromatography를 이용하여 3개의 flavonoid 화합물을 분리하였다. 각 화합물의 화학구조는 NMR 스펙트럼 데이터 해석 및 표품과의 HPLC 직접 비교를 통하여 kaempferol-3-O-s
Activity-guided fractionation of an ethyl acetate (EtOAc)-soluble portion of an ethanolic extract from the leaves of cultivated mountain ginseng, using pancreatic lipase inhibition assay, led to the isolation and identification of three flavonoids of a previously described structure, kaempferol-3-O-sophoroside (I), kaempferol-3-O--Dglucopyranoside (astragalin, II) and kaempferol (III). All compounds (I.III) showed pancreatic lipase inhibitory activities, with values ranging from to , kaempferol (III) showed the most potent inhibitory activity with an of . The level of activity may depend on the number of C-3 glucosyl group(s) linked to the kaempferol backbone, and the isolated compounds may have promise as pancreatic lipase inhibitors.
