The purpose of this study was to investigate the effect of Cheonggukjang pills with aronia and blueberries on dextran sulfate sodium (DSS)-induced colitis in mice. There have been several reports that Cheonggukjang is effective for intestinal health, but the efficacy of Cheonggukjang containing fruits has not yet been reported. In this study, we showed the effect of cheonggukjang pills with blueberries and aronia (CPBA) on DSS-induced colitis in BALB/c mice. CPBA was obtained from Soonchang Moonokae foods and orally administered once a day for 2 weeks before DSS treatment. Colitis was induced in mice by feeding 5% (w/v) DSS drinking water for 7 days. The results showed that CPBA treatment significantly alleviated DSS-induced disease activity index associated with a decrease in colon length. CPBA improved DSS-induced histological changes and intestinal epithelial barrier integrity in mice colon. In addition, CPBA administration significantly reduced the levels of DSS-mediated interferon-γ and interleukin-6 in serum and tumor necrosis factor-α in colon tissue. Moreover, the gene expression of COX-2 and iNOS, which are factors involved in inflammatory signaling, was significantly reduced by CPBA treatment. These results suggest that CPBA have a protective effect against DSS-induced mice colitis and may be a candidate for colitis treatment.

Abstract
서 론
재료 및 방법
    1. 실험재료
    2. 실험동물
    3. 급성 대장염 모델 제작
    4. 질병활성도 분석
    5. 혈액 및 조직학적 분석
    6. 유전자 발현 분석
    7. 통계분석
결과 및 고찰
    1. CPBA가 DSS로 유도한 대장염 마우스 모델에서 대장염 완화에 미치는 영향
    2. CPBA 투여가 대장염 마우스 장조직의 병리학적 변화에 미치는 영향
    3. CPBA가 혈액 및 대장 조직내 염증관련 사이토카인 함량에 미치는 영향
    4. 대장 조직에서의 염증 반응 조절 관련 신호전달 인자발현 분석
요약 및 결론
References

• 김하림((재)전주농생명소재연구원 연구원) | Ha-Rim Kim (Researcher, Jeonju AgroBio-Materials Institute, Jeonju 54810, Korea)
• 노은미((재)전주농생명소재연구원 연구원) | Eun-Mi Noh (Researcher, Jeonju AgroBio-Materials Institute, Jeonju 54810, Korea)
• 이승현((재)전주농생명소재연구원 연구원) | Seung-Hyeon Lee (Researcher, Jeonju AgroBio-Materials Institute, Jeonju 54810, Korea)
• 조종현(순창문옥례식품(주) 대표) | Jong Hyun Cho (Chairman, Soonchang Moonokrae Foods Corp., Sunchang 56048, Korea)
• 박미희((재)전주농생명소재연구원 선임연구원) | Mi Hee Park (Senior Researcher, Jeonju AgroBio-Materials Institute, Jeonju 54810, Korea)
• 김선영((재)전주농생명소재연구원 융복합연구사업본부장) | Seon-Young Kim (Head Manager, Convergence R&DB Division, Jeonju AgroBio-Materials Institute, Jeonju 54810, Korea) Corresponding Author