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Effects of dietary acetaminophen, vitamin C and thioctic acid supplements on stress responses in mice vaccinated with foot-and-mouth disease vaccine KCI 등재

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예방수의학회지 (Journal of Preventive Veterinary Medicine)
한국예방수의학회(구 한국수의공중보건학회) (The Korean Society of Preventive Veterinary Medicine)
초록

This study evaluated the effect of a combination of acetaminophen (AAP), vitamin C (VC) and thioctic acid (TA) on reducing serum cortisol concentrations in mice with foot-and-mouth disease (FMD) vaccination. For 5 days from 3 days before FMD vaccination to 2 days after vaccination, mice were orally administered with AAP 600 mg/kg feed (n=25, AAPT), combination of AAP 600 mg and VC 200 mg per kg feed (n=25, AVCT) and combination of AAP 600 mg, VC 200 mg and TA 20 mg per kg feed (n=25, AVTT), respectively. From day 1 to day 7 after FMD vaccination, the cortisol concentration of all groups treated with the drug was significantly decreased compared to that of the positive control group with FMD vaccination (p<0.05). In conclusion, the combined treatment of AAP, VC and TA was the most effective in relieving stress from FMD vaccination compared to the single treatment.

목차
Abstract
감사의 글
REFERENCES
저자
  • Jin-Kyoung Kim(Department of Dental Hygiene, Daegu Health College)
  • Song-Ee Son(Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University)
  • Won-Seok Chae(Division of Life-Science and Chemistry, Daejin University)
  • Suk Kim(Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University)
  • Hu-Jang Lee(Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) Corresponding Author