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Mitochondrial oxidative stress regulatory approaches for diabetic encephalopathy KCI 등재

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  • URLhttps://db.koreascholar.com/Article/Detail/420176
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충북대학교 동물의학연구소 (Research Institute of Veterinary Medicine, Chungbuk National University)
초록

Diabetic encephalopathy is a major complication with cognitive impairment and neurodegeneration in patients with type 1 or type 2 diabetes mellitus (DM). DM-induced glucolipotoxicity is a risk factor for Alzheimer’s disease–like phenotype, including amyloidogenesis, tau hyperphosphorylation, and neuronal apoptosis. Although the detailed mechanism underlying the pathogenesis of diabetic encephalopathy remains unclear, mitochondrial oxidative stress is emerging as a key factor for diabetic complications and neurodegeneration. A deeper understanding of the regulatory mechanism of mitochondrial oxidative stress under hyperglycemic conditions will provide insights into the development of therapeutic strategies for diabetic encephalopathy. Here, we review the role of mitochondrial oxidative stress in diabetic encephalopathy and the regulatory mechanisms by which high glucose induces the generation of mitochondrial reactive species oxygen species in neuronal cells. This review also summarizes the mitochondrial-dependent and -independent pathways (O-linked-N-acetylglucosaminylation, calcium, and glycogen synthase kinase 3β signaling) that regulate mitochondrial oxidative stress in a DM model.

목차
Abstract
General introduction of diabetic encephalopathy
Glucose transporter (GLUT) in diabetic encephalopathy
Effect of high glucose on neurodegeneration
Mitochondrial oxidative stress in diabetic encephalopathy
Effect of high glucose on mitochondrial dynamics and nuclearfactor erythroid 2–related factor 2 (Nrf2)-regulatedantioxidative system
Role of calcium in diabetic encephalopathy
Role of O-linked-N-acetylglucosaminylation (O-GlcNAcylation)in diabetic encephalopathy
Role of glycogen synthase kinase 3β (GSK3β) signaling indiabetic encephalopathy
Conclusion
REFERENCES
저자
  • Hye Jih Kim(College of Veterinary Medicine and Veterinary Medicine Center, Chungbuk National University, Institute for Stem Cell & Regenerative Medicine (ISCRM), Chungbuk National University)
  • Dae Hyun Kim(College of Veterinary Medicine and Veterinary Medicine Center, Chungbuk National University, Institute for Stem Cell & Regenerative Medicine (ISCRM), Chungbuk National University)
  • Hang Hyo Jo(College of Veterinary Medicine and Veterinary Medicine Center, Chungbuk National University, Institute for Stem Cell & Regenerative Medicine (ISCRM), Chungbuk National University)
  • Hyun Jik Lee(College of Veterinary Medicine and Veterinary Medicine Center, Chungbuk National University, Institute for Stem Cell & Regenerative Medicine (ISCRM), Chungbuk National University) Corresponding author