Abstract Biosensors are a group of measurement systems and their design is based on the selective identification of analyses based on biological components and physical and chemical detectors. Biosensors consist of three components: biological element, detector, and converter. The design of biosensors in various fields of biological sciences, medicine has expanded significantly. Biosensor technology actually represents a combination of biochemistry, molecular biology, chemistry, physics, electronics, and telecommunications. A biosensor actually consists of a small sensor and biological material fixed on it. Because biosensors are a powerful tool for identifying biological molecules, today they are used in various medical sciences, chemical industry, food industry, environmental monitoring, pharmaceutical production, health, etc. In fact, these sensors are a powerful tool to identify biological molecules. In fact, biosensors are analytical tools that can use biological intelligence to detect and react with a compound or compounds, and thus create a chemical, optical, or electrical message. The basis of a biosensor is to convert a biological response into a message. In this category, the use of telecommunication engineering technology and electromagnetic waves and frequency and radio spectrum is growing more and more to detect, measure, and determine the desired parameters in microbiology and laboratory sciences. The use of radio, optical, electromagnetic, ultrasonic, and infrared wave detection technology is part of the applications of telecommunication science in this field. Even image and audio processing systems have been instrumental in the discussion of biosensors in microbiology. The science of using fiber optics and waveguides, micro-strip antennas, and microelectromechanical technology is also very efficient in the construction and design of these biosensors.

    Abstract
    1 Introduction
    2 Classification based on biomarkers
        2.1 Antibodyantigen
        2.2 Enzymes
        2.3 Nucleic acids
        2.4 Cells
        2.5 Biomimetic materials
        2.6 Binding of biological elements to the surface
        2.7 Classification of biosensors based on biotransformation system
        2.8 Evaluate the performance of a biosensor
    3 Graphene
    4 Properties of monolayer and bilayer graphene
        4.1 Properties of multilayer graphene
        4.2 Graphene synthesis methods
    5 Biosensors-based graphene
    6 Comparison of electrochemical activity of GC and CNTs
        6.1 GC-based optical biosensors
    7 Field effect transistor biosensors
    8 Improving graphene bio-sensing with metal nanoparticles
    9 Conclusion
    References

• Walid Kamal Abdelbasset(Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Department of Physical Therapy, Kasr Al‑Aini Hospital, Cairo University)
• Saade Abdalkareem Jasim(Medical Laboratory Techniques Department, Al-Maarif University College)
• Dmitry Olegovich Bokov(Institute of Pharmacy, Sechenov First Moscow State Medical University, Laboratory of Food Chemistry, Federal Research Center of Nutrition, Biotechnology and Food Safety)
• Maria Sergeevna Oleneva(Institute of Pharmacy, Sechenov First Moscow State Medical University)
• Anvar Islamov(Department of Education, Kokand University)
• Ali Thaeer Hammid(Department Baghdad, Imam Ja’afar Al-Sadiq, University Computer Engineering)
• Yasser Fakri Mustafa(Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul)
• Ghulam Yasin(Department Botany, Bahauddin Zakariya University)
• Arnold C. Alguno(Department of Physics, Mindanao State University - Iligan Institute of Technology)
• Ehsan Kianfar(Department of Chemical Engineering, Arak Branch, Islamic Azad University, Young Researchers and Elite Club, Gachsaran Branch, Islamic Azad University)