This study examined the subacute oral toxicity of Dendropanax morbiferus H.Lév leaves hot-water extracts (DMWE) using male and female Spargue-Dawley rats. Rats were orally administered the DMWE at dose levels of 0, 250, 500, 1,000, and 2,000 mg/kg body weight (BW) for four weeks. For experimental period, clinical signs and the number of deaths were examined, and feed intake and BW of all experimental animals were measured once a week for four weeks. At the end of the experiment, blood samples were collected from all rats, and all animals were euthanized and autopsies were performed to collect major organs. No dead animals were found during the experimental period. In addition, no differences were found between control and DMWE-treated groups in feed intakes, BW changes, organ weights, clinical signs, hematological parameters, and serum biochemical parameters. The results of this study provided evidence that oral administration of DMWE at the dose of 2,000 mg/kg BW is safe in rats and may not exert severe toxic effects.

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REFERENCES

• Jiyong Park(College of Veterinary Medicine, Gyeongsang National University)
• Chang-Soo Cho(College of Veterinary Medicine, Gyeongsang National University)
• Jun-Ho Song(College of Veterinary Medicine, Gyeongsang National University)
• Kwang Il Park(College of Veterinary Medicine, Gyeongsang National University)
• Yeung Bae Jin(College of Veterinary Medicine, Gyeongsang National University)
• Woo Hyun Kim(College of Veterinary Medicine, Gyeongsang National University)
• Suk Kim(College of Veterinary Medicine, Gyeongsang National University)
• Hu-Jang Lee(College of Veterinary Medicine, Gyeongsang National University) Corresponding author