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pp.219-230
This research aims to study the changes in gastrointestinal function attributed to aging in human. The thresholds for recognition and detection of flavors became elevated and salivary gland acinar cells decreased in the old age. But most esophageal function remained relatively intact. Although gastric emptying time has been slowed with aging, the total intestinal transit time did not differ. Atropic gastritis due to H. pylori in old man decreased secretion of acid and intrinsic factor and absorbability of calcium and iron. Pancreatic secretion is droped in older persons. Prevalence of gallstones rised with age. Liver size and portal blood flow decreased significantly with age. Mucosal surface area has been reported to be slightly diminished in the aging man. Glucose transporters decreased and insulin tolerance increased. Absorption of aromatic amino acid is diminished with age. Dietary protein in that aging human increased fecal nitrogen excretion. Vitamin A tolerance increased. Vitamin D receptor concentration decreased and resistance to 1, 25-(OH)_2D_3 action increased. Permeability of aging small intestine increased. Zinc balance dit not differ. Copper absorption appeared not to be significantly affected by age. Neurotensin secretion decreased thus slowed colonic peristaltic movements and intestinal mucosal growth.
