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pp.59-69
Plasma cholesterol함량은 n6 LA에 의한 영향은 없었으며 n3 LL와 EPA의 순으로 감소되어 plasma cholesterol의 저하는 EFA가 가장 효과적이었다. Plasma TG함량은 CO, PO, FO군에서 모두 낮았으며 특히 PO, FO군에서 유의성있게 감소되었다. n6 LA의 경우 plasma와 간조직의 TG함량은 n6 LA에 의해 감소되었으나. lipogenic enzyme활성도는 변화가 있었다. n3 LL를 투여한 PO군의 경우 plasma와 간의 TG함량은 n6 LA에서와 마찬가지로 감소된 반면, lipogenic enzyme활성은 다소 증가되었으나 간의 TG합성을 증가시킬 정도는 아니었다. n3 EPA에 의해 plasma TG는 BT군에 비해 유의성있게 감소되었으며 lipogenic enzyme활성이 낮아졌음에도 불구하고 간의 TG함량은 BT군에 비해 변화가 없었다. Plasma와 간조직의 지방산 조성은 식이지방산에 의한 영향이 잘 나타났는데 CO군은 C_18:2와 C_20:4의 양, C_20:4/C_20:5의 비율이 높았다. PO군은 C_18:3과 C_20:5, C_22:6의 양이 증가되어 C_20:4/C_20:5의 비율이 남았으며 FO군에서는 C_20:5와 C_22:6양이 가장 높게 나타났으며 따라서 C_20:4/C_20:5의 비율은 가장 낮았다.
This study designed to compare the hypolipidemic effects of n6 linoleic acid(LA), n3 α-linolenic acid(LL) and n3 eicosapentaenoic acid(EPA) and docosahexaenoic acid(DHA) in rats fed high fat (40% Cal) diet. Male Sprague-Dawley rats fed experimental diets for 6 weeks, which were different only in fatty acid composition. The dietary fats were beef tallow (BT) as a source of saturated fatty acid (SFA), corn oil (CO) for n6 LA, perilla oil(PO) for n3 α-LL and fish oil(FO) for n3 EPA+DHA. Plasma total cholesterol (T-chol) level was increased by n6 LA but decreased by n3 LL and n3 EPA+DHA and most effectively reduced by n3 EPA+DHA. Plasma triglyceride(TG) level was reduced by n6 LA, but lipogenesis in liver was not affected by n6 LA. However, plasma TG level was lowered by n3 LL and EPA+DHA. Both lipogenic enzyme activity and liver TG level were also decreased by n3 PUFA. PO and FO groups were significantly higher in the relative proportions of C_20:5 and C_22:6 of plasma and liver and lower in those of C_20:4/C_20:5 ratio. Overall, the lipid-lowering effect was in the order of n3 EPA+DHA >n3 LL >n6 LA and fish oil and perilla oil rich in n3 PUFA may have important nutritional applications in the prevention and treatment of hyperlipidemia.
