In probiotics production, lactic acid bacteria (LAB) are cultured on a large scale to achieve efficient processing through fermentation optimization and scale-up. In this Current study, the LAB strain Lactiplantibacillus plantarum WiKim0125 was isolated from kimchi and optimized the production. The optimization strategy for cultivating L. plantarum WiKim0125 consisted of investigating media components, selecting physiochemical conditions to enhance productivity, and scaling up for pilot-scale production. Each process condition was evaluated based on substrate consumption, lactic acid production, and viable cell yield. As a result, the final viable cell and lactic acid yield of L. plantarum WiKim0125 increased by 38.6% and 19.4%, respectively. This study provides an overview of fermentation optimization and scale-up processes for the industrial application of L. plantarum WiKim0125.

서 론
재료 및 방법
    사용 균주
    배양 특성 분석을 위한 균체 수율, 기질 소비, 대사산물 생산량측정
    균체 및 젖산 생산 최적화
결과 및 고찰
    배지 조성 최적화
    최적 배양 조건 탐색
    최적 배지 및 배양 조건을 이용한 대량 배양
    유산균 동결건조 분말 생존율 비교
요약
감사의 글

• 김영열(세계김치연구소 기술혁신연구본부, 전남대학교 융합식품바이오공학과) | Yeong Yeol Kim (Technology Innovation Research Division, World Institute of Kimchi, Gwangju 61755, Republic of Korea, Department of Integrative Food, Bioscience and Biotechnology, Chonnam National University, Gwangju 61186, Republic of Korea)
• 김슬비(세계김치연구소 기술혁신연구본부, 전남대학교 농화학과) | Seulbi Kim (Technology Innovation Research Division, World Institute of Kimchi, Gwangju 61755, Republic of Korea, Division of Applied Bioscience & Biotechnology, Chonnam National University, Gwangju 61186, Republic of Korea)
• 김정환(세계김치연구소 기술혁신연구본부, 경북대학교 식품생물공학과) | Jung Hwan Kim (Technology Innovation Research Division, World Institute of Kimchi, Gwangju 61755, Republic of Korea, School of Food Science and Biotechnology, Kyungpook National University, Daegu 41566, Republic of Korea)
• 김호명(세계김치연구소 기술혁신연구본부) | Ho Myeong Kim (Technology Innovation Research Division, World Institute of Kimchi, Gwangju 61755, Republic of Korea) Corresponding author