Purpose: This study was conducted to understand the ethical climate, nursing practice environment, and ethical sensitivity of hospital nurses, and to investigate the influence of the ethical environment and nursing practice environment on ethical sensitivity. Methods: The subjects of the study were 137 nurses with at least one year of work experience. Date collection was conducted from July to August 2021, using the IBM SPSS Statistics 26.0 for Windows program(IBM Corp. Armont, NY, USA), the frequency and percentage, mean and standard deviation and Independent t-test, one-way ANOVA, Pearson’s correlation, Multiple regression analysis. Results: As a result of the study, the ethical sensitivity of hospital nurses showed statistically significant differences according to age, marital status, position, and ethical educational experience. Ethical sensitivity was found to have a significant positive correlation between all sub-factors of the ethical environment and all sub-factors of the nursing practice environment. Among the sub-factors of the ethical environment, the factor influencing ethical sensitivity in this study is ‘relationship with peers (β=.20, p=.034) ’ and ‘relationship with manager (β=.24, p=.023) and the explanatory power was 42.0%, which was statistically significant (F=8.26, p<.001). Conclusion: This study confirmed that ‘relationship with peers’ and ‘relationship with managers’ influence ethical sensitivity among ethical environments. Therefore, it will be necessary to form a positive relationship between peers and managers to improve the ethical sensitivity of hospital nurses.