Graphene-based sensors have emerged as significant tools for biosensing applications due to their unique electrical, mechanical, and thermal properties. In this study, we have developed an innovative and sensitive aptasensor based on the surfacemodified graphene for the detection of lung cancer biomarker CA125. The sensor leverages the combination of graphene surface and gold nanoparticles (AuNPs) electrodeposition to achieve a high level of sensitivity and selectivity for the biomarker detection. A noticeable decrease in electron transfer resistance was observed upon the AuNPs deposition, demonstrating the enhancement of electrochemical performance. Our experimental findings showed a strong linear relationship between the sensor response and CA125 concentrations, ranging from 0.2 to 15.0 ng/mL, with a detection limit of 0.085 ng/ mL. This study presents a novel approach to lung cancer detection, surpassing the traditional methods in terms of invasiveness, cost, and accuracy. The results from this work could pave the way for the development of graphene-based sensors in various other biosensing applications.

A graphene-based highly sensitive aptasensor for the detection of lung cancer marker CA125
    Abstract
    1 Introduction
    2 Experimental
        2.1 Materials
        2.2 SPE fabrication
        2.3 Preparation of aptamer sensors
        2.4 Electrochemical detection
    3 Results and discussion
    4 Conclusion
    References

• Junnan Chen(Department of Cardio‑Thoracic Surgery, Sanmen People’s Hospital, Taizhou, Zhejiang, China)
• Lingmin Yu(Sanmen County Medical Emergency Center, 171 Renmin Road, Sanmen County, Taizhou, Zhejiang, China)
• Wenzhen Xu(Department of Cardio‑Thoracic Surgery, Sanmen People’s Hospital, Taizhou, Zhejiang, China)
• Tao Lin(Department of Cardio‑Thoracic Surgery, Sanmen People’s Hospital, Taizhou, Zhejiang, China)
• Sicong Jiang(Division of Thoracic and Endocrine Surgery, University Hospitals and University of Geneva, 1211 Geneva 4, Switzerland)
• Caijin Jin(Department of Cardio‑Thoracic Surgery, Sanmen People’s Hospital, Taizhou, Zhejiang, China)