The high-level nuclear waste (HLW) repository is a 500-1,000 m deep underground structure to dispose high-level nuclear waste. The waste has a very long half-time and is exposed to a number of stresses, including high temperatures, high humidity, high pressure These stresses cause the structure to deteriorate and create cracks. Therefore, structural health monitoring with monitoring sensors is required for safety. However, sensors could also fail due to the stresses, especially high temperature. Given that the sensors are installed in the bentonite buffer and the backfill tunnel, it is impossible to replace them if they fail. That’s why it is necessary to assess the sensors’ durability under the repository’s environmental conditions before installing them. Accelerated life test (ALT) can be used to assess durability or life of the sensors, and it is important to obtain the same failure mode for reliability tests including ALT. Before conducting the test, the proper stress level must be designed first to get reliable data in a short time. After that, acceleration of life reduction with increasing temperature and temperature-life model should be determined with some statistical methods. In this study, a methodology for designing stress levels and predicting the life of the sensor were described.