The International Atomic Energy Agency (IAEA) Safety Fundamentals No. SF-1 Safety Principle 7 states that people and the environment, present and future, must be protected against radiation risk. Therefore, it is important to evaluate the safety of radioactive waste repositories on a longterm time scale to ensure future safety. However, IAEA-TECDOC-767 states that the long-term time scale of interest means that the risk or dose to future individuals cannot be reliably predicted because it relies on assumptions. Therefore, evaluating the safety of long-term time scales should use safety indicators that are less dependent on assumptions. Radiotoxicity is one of the safety indicators that represent an inherent risk from radioactive waste. It has been mainly used to show the time required until the hazard presented by waste decreases to that of natural uranium ore and is easy to use in communication with the public. There are several methods for calculating Radiotoxicity. Radioactivity is multiplied by a Dose Conversion Factor (DCF) to be expressed in Sv units, or radioactivity be divided into Maximum Permissible Concentration (MPC) to be expressed in m3 units as the amount of water needed to dilute the radionuclide to the permitted level. It is also often made dimensionless through comparison with reference materials like uranium ore. Radiotoxicity varies in size several times, even if it is a waste of similar origins and components, depending on the Radiological variable (e.g., Annual Limitation Intake (ALI), Dose Conversion Factor (DCF), Maximum Permissible Concentration (MPC), Activity). Therefore, this study was conducted to determine whether there was a significant difference when different radiological variables were substituted. This study compares and analyzes their differences using various MPCs or DCFs used in each country. In addition, this study analyzes radionuclides that influence radiotoxicity with several radiological variables. This study introduces the effects of substituting different radiological variables.