For the disposition of radioactive wastes generated from nuclear power plant, radioisotope inventory must be analyzed to determine an activity concentration of radionuclides. Radionuclides in low- and intermediate-low-level of radioactive wastes, however, can be easily classified to easyto- measure (ETM) and difficult-to-measure (DTM) nuclides. ETM nuclides are gamma emitting nuclides that is relatively easy to measure because they do not need to be destroyed for the preprocessing. On the other hands, DTM nuclides are alpha and beta emitting nuclides that need to be destroyed for the preprocessing and also need chemical separation. Currently, measurement methods for DTM nuclides are developed and in this paper measurement methods of Fe-55, Ni-59, Ni-63, Sr-90 and Tc-99 will be introduced.