The idea of phytosanitation has continuously received attentions since 1950s, as the volume of international trade began to rise. All aspects of phytosanitation, including regulatory framework as well as the supporting technologies and sciences, have developed intercorrelatedly to the exponential growth of the trade, for the protection of an importing country’s agriculture, landscape, and industries from potential damages by invasive non-native pests. Phytosanitary regulatory framework has chiefly been developed by the International Plant Protection Convention (IPPC), which is the foundation of the standardized phytosanitary measures across the borders, as delineating roles/responsibilities of every stakeholder on a trade continuum. Changes and modifications on the framework will be continuously required to cope with the on-going challenges by invasive non-native pests. Its role is no longer limited to plant protection but has blended into other frameworks, such as biosecurity and food safety.