These studies were conducted to investigate the effects an herbal extract composition(MHE) containing Hovenia dulcis T., Artemisa capillaris T., Pueraria thunbergiana B., Polygonatum falcatum A., Agastache rugosa O., Silybum marianum L. and Glycyrrhiza uralensis F. in alcohol administered mice. Prophylactic administration of different doses of MHE(20~100 ㎎/㎏) had beneficial actions toward alcohol degradation in acute alcohol treated mice. In addition, intraperitoneal administration of the MHE showed anti-inflammatory effects in inhibition tests of vascular permeability produced by acetic acid. MHE also reduced the concentrations of nitric oxide(NO) and tumor necrosis factor(TNF)-α in macrophages that were activated by LPS. These results demonstrate that MHE possesses the potential to stimulate alcohol degradation and inhibit inflammatory effects in mice.

• 최웅 | Ung Choi