In this paper, a simple, cost-effective, and efficient electrochemical sensor for molecular imprinting melatonin was established. The molecular imprinted films were formed by in situ electrochemical polymerization using molecular imprinting technology. The modification method, modification time and other parameters of the electrode were optimized. Under optimized conditions, the sensor responds to melatonin concentration in a linear range of 0–100 μM. The detection limit was 0.171 μM. In addition, the sensor has little response to interfering substances, such as uric acid, vitamin B6, vitamin C, and glucose, and can be tested in real samples. The recoveries were 98.73–101.60%.

Highly sensitive electrochemical detection of melatonin based on graphene-assisted molecular imprinting technology
    Abstract
    1 Introduction
    2 Experimental
        2.1 Chemicals and instruments
        2.2 Preparation of molecular imprinting sensor
    3 Results and discussion
    4 Conclusion
    References

• Bin Sun(Department of Neurosurgery, Cheeloo College of Medicine, Qilu Hospital (Qingdao), Shandong University, Shandong 266035, China)
• Wei Sun(Department of Neurology, Third People’s Hospital of Qingdao, Qingdao 266000, Shandong, China)
• Zhigang Wang(Department of Neurosurgery, Cheeloo College of Medicine, Qilu Hospital (Qingdao), Shandong University, Shandong 266035, China)
• Bo Zhao(Department of Neurosurgery, Jiaozhou Branch, East Hospital of Tongji University, Shandong 266300, China)
• Song Yang(Department of Neurosurgery, Jiaozhou Branch, East Hospital of Tongji University, Shandong 266300, China) Corresponding author