The objective of this study is to identify the priority of elements for effective implementation of MES in small and medium-sized manufacturing enterprises trying to develop into smart factories. For this purpose, the Delphi method and the Analytic Hierarchy Process(AHP) mothod are applied. As a result of the study, the cooperation of the members in the supply chain is the most important factor for small and medium-sized enterprises in order to survive in the global competitive environment. Therefore, the enterprises need to make various efforts to create synergies through the technical strength of suppliers and the cooperation in the process of introducing and operating MES.