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Effect of functional food containing low-molecular-weight chito oligosaccharide on mice induced to become obese by high-fat diet KCI 등재

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예방수의학회지 (Journal of Preventive Veterinary Medicine)
한국예방수의학회(구 한국수의공중보건학회) (The Korean Society of Preventive Veterinary Medicine)
초록

Obesity occurs when the body consumes more energy than it requires and uses less energy, resulting in the accumulation of fat, which increases the number and size of fat cells in the body. It causes high blood pressure, type 2 diabetes, and joint crowding, making it difficult to fully treat. We investigated the effects of chito oligosaccharide(CHO) functional material, which suppresses fat accumulation, restores dyslipidemia values, and has no side effects.In this study, we investigated the ameliorative effects of CHO on obese mice fed a high-fat diet. The experimental groups were divided into 5 groups (n=10) of C57BL/6 mice: normal control (N), control group (C), and chito oligosaccharide low concentration (L), medium concentration (M), and high concentration (H) groups. We tested whether CHO has an effect on obesity through body weight and adipose tissue weighing, serum lipid testing, and histological examination. Experimental analysis showed that CHO reduced body weight and adipose tissue weight, improved the concentrations of TCHO, TG, HDL, and LDL, which are factors for dyslipidemia diagnosis, and decreased the diameter size of adipose tissue. These results suggest that CHO alleviates the levels of fat growth inhibition and dyslipidemia levels in obese-induced mice, and has a positive effect on obesity.

목차
서 론
재료 및 방법
    재료 및 추출
    군 구성 및 비만 유발
    체중 및 체중 증가량 측정
    혈청 및 조직 채취
    혈청 내 간손상 지표 및 비만 인자 측정
    영상학적 분석
    병리조직학적 분석
    통계
결 과
    체중 및 체중 증가량
    지방 무게
    혈청 분석
    영상학적 분석
    조직병리학적 평가
고 찰
감사의 글
REFERENCES
저자
  • Sunju So(Center for Animal Resources Development, WonkwangUniversity, Iksan 54538, Korea)
  • OKjin Kim(Center for Animal Resources Development, WonkwangUniversity, Iksan 54538, Korea)
  • Hye-Yeong Kwon(Center for Animal Resources Development, WonkwangUniversity, Iksan 54538, Korea)
  • Hyun-A Lee(Center for Animal Resources Development, WonkwangUniversity, Iksan 54538, Korea) Corresponding author