The diagrid structural system has a braced frame that simultaneously resists lateral and vertical loads, and is being applied to many atypical high-rise buildings for aesthetic effects. In this study, a 60-story structure with twisted degrees of 0° to 180° was selected to determine seismic response control performance of twisted high-rise structures whether the diagrid system was applied and according to the reduction of braced frame material quantity. For this purpose, ‘Nor’ model without the diagrid system and the ‘DS’ model with the diagrid system, which was modeled by reducing braced frame member section to 700~400, were modeled. As a result, the 'DS' model showed an seismic response control effect in all Twisted models even when the quantity was reduced, and especially, the Twisted shape model was found to have an superior response control effect compared to the regular structure. In addition, the ‘600DS’ analysis model, which matched the ‘Nor’ model by 99.0% in quantity, showed an increase in seismic response control performance as the rotation angle increased.