This experimental study aimed to determine the anti-obesity effects of burdock(Arctium lapp L.) extract and processed (Beopje) burdock extract in a high fat diet-induced obesity model. When burdock extract was orally administered at a concentration of 250 mg/kg BW and the Beopje burdock extract was administered at 250 and 500 mg/kg BW, they significantly decreased body weights increased by a high-fat diet, improved food efficiency ratio, decreased adipose tissue weight by site, and significantly decreased blood triglycerides, total cholesterol, and LDL-cholesterol levels. Blood ALT and AST contents as liver function-related indices increased by the high fat diet were significantly decreased by the Beopje burdock extract. Results of histological analysis of the liver showed that the Beopje burdock extract alleviated fatty liver phenomenon induced by a high-fat diet. In addition, levels of blood TNF-α, IL-6, and IL1-β increased by a high-fat diet were significantly decreased by ALB-L and ALB-H. Therefore, Beopje burdock extract can improve obesity in a high-fat diet-induced obese animal model by improving blood lipids and blood biochemical indices, increasing body water, and decreasing body fat more than the burdock extract.

Abstract
서 론
재료 및 방법
    1. 시료물질제조
    2. 실험동물 사육조건
    3. 고지방식이 유도 비만동물모델
    4. 시료 및 혈액 채취
    5. 혈중 지질농도 측정 및 생화학적 지표분석
    6. 간과 지방 조직학적 변화 관찰 (H&E 염색)
    7. 통계 분석
결과 및 고찰
    1. 실험동물의 체중, 체중증가율, 식이효율 변화
    2. 지방조직 무게 변화
    3. 장기무게 변화
    4. 체성분(수분과 지방) 변화
    5. 혈중 생화학지표 농도 변화
    6. 혈중 지질 농도의 변화
    7. 혈중 TNF-α, IL-6 및 IL-1β 농도
    8. 실험동물의 간 및 지방조직의 병리학적 변화
요약 및 결론
References

• 김정원(호서대학교 벤처대학원 융합공학과 박사과정 학생, 호서대학교 보건산업연구소 연구원) | Jung Won Kim (Ph.D. Student, Dept. of Convergence Technology, Graduate School of Venture, Hoseo University, Seoul 06724, Korea, Researcher, Institute of Health Industry, Hoseo University, Seoul 06724, Korea)
• 강순아(호서대학교 벤처대학원 융합공학과 교수, 호서대학교 보건산업연구소 소장) | Soon Ah Kang (Professor, Dept. of Convergence Technology, Graduate School of Venture, Hoseo University, Seoul 06724, Korea, Director, Institute of Health Industry, Hoseo University, Seoul 06724, Korea) Corresponding author