A red-crowned crane (Grus japonensis) from Seoul Zoo died with mild anorexia and sudden respiratory distress. A white globoid mass in the abdominal cavity and multifocal nodules in the kidneys were identified on the necropsy. Histologic examination showed anaplastic, solid patterned neoplastic cells in the kidneys and the mass. Immunohistochemistry for pancytokeratin and PAX8 was positive, while heterogeneous antigen expression was present in poorly differentiated neoplastic cells. Overall, the neoplastic changes in the kidneys and the mass were consistent with a renal origin. This case highlights the possibility of further discoveries of metastatic renal cell carcinomas in cranes.

• Dong-Youb Shin(Preclinical Resource Center, Samsung Medical Center, 81, Irwon-ro, Gangnam-gu, Seoul 06351, Korea)
• Jung-Hyang Sur(Komipharm International Co., 17, Gyeongje-ro, Siheung-si, Gyeonggi-do, 15094, Korea)
• Yong-Gu Yeo(Conservation and Health Center, Seoul Zoo, 102, Daegonwongwangjang-ro, Gwacheon-si, Gyeonggido, 13829, Korea)
• Jang-Won Son(Conservation and Health Center, Seoul Zoo, 102, Daegonwongwangjang-ro, Gwacheon-si, Gyeonggido, 13829, Korea)
• Nong-Hoon Choe(Department of Veterinary Public Health, College of Veterinary Medicine, Konkuk University, 120, Neungdong-ro, Gwangjin-gu, Seoul 05029, Korea) Corresponding author