Purpose: This study aimed to explore the effects of immersion, satisfaction, and confidence in nursing competence after simulation practice. Methods: A descriptive survey was administered to 138 senior nursing students. Data were analyzed using descriptive statistics, Pearson’s correlation, stepwise multiple regression, and Cronbach’s alpha coefficient using SPSS/WIN 27.0. Results: Immersion, satisfaction, confidence, and nursing competence scored 85% of the overall scores. Nursing competence was positively correlated with immersion, confidence, and satisfaction. Only immersion had a significant effect on nursing competence, explaining 55.8% of variance. Conclusion: The level of immersion must be increased to enhance nursing competence in simulation. Further studies are needed to examine the effects of immersion on nursing competencies.