목적 : 본 연구는 세륨(IV)-지르코늄(IV) 산화물 나노입자를 사용하여 콘택트렌즈를 제조한 후, 안의료용 기능성 렌즈로의 사용 가능을 확인 위해 제조된 렌즈의 물성을 비교 분석하였다. 방법 : 2-Hydroxyethyl methacrylate에 나노 세륨-지르코늄 산화물(cerium(IV)-zirconium(IV) oxide)을 첨가하여 공중합 한 후 물성을 측정하고, 친수성 단량체인 methacrylic acid(MA)를 추가로 첨가하여 물성을 측정, 비교하였다. 결과 : 다양한 비율의 세륨(IV)-지르코늄(IV) 산화물 나노입자와 MA를 첨가한 렌즈의 물성을 평가한 결과, UV-B 투과율은 40.95~66.26%, 굴절률 1.4163~1.4357, 함수율 37.44~47.18%, 접촉각 36.87~56.36°, 인장 강도 0.0612~0.561 kgf/mm², 표면거칠기 7.70~8.72 nm로 각각 측정되었다. 나노입자 및 MA 첨가는 습윤성, 인장강도 및 중합안정성을 향상시키고, UV-B 투과율과 표면거칠기를 감소시켰으며, 황색포도상구균에 대한 항균 성이 확인되었다. 결론 : 세륨(IV)-지르코늄(IV) 산화물 나노입자에 MA를 첨가하여 제조한 렌즈가 중합 안정성, 내구성, 습윤성 을 향상시키는 것을 확인하였으며, 따라서 안의료용 기능성 콘택트렌즈 소재로 활용할 수 있을 것으로 판단된다.

Purpose : This study was designed to investigate the potential use of contact lenses made with cerium(IV)-zirconium(IV) oxide nanoparticles as functional ophthalmic lenses by comparing and analyzing the physical properties of the manufactured lenses. Methods : Nano cerium(IV)-zirconium(IV) oxide was added to 2-hydroxyethyl methacrylate (HEMA) and copolymerized. The physical properties were measured. Then, methacrylic acid (MA), a hydrophilic monomer, was added to further evaluate and compare the physical properties. Results : The physical properties of lenses manufactured with various ratios of cerium(IV)- zirconium(IV) oxide nanoparticles and methacrylic acid (MA) were evaluated. UV-B transmittance ranged from 40.95% to 66.26%, refractive index from 1.4163 to 1.4357, water content from 37.44% to 47.18%, contact angle from 36.87° to 56.36°, tensile strength from 0.0612 kgf/mm² to 0.561 kgf/mm², and surface roughness from 7.70 nm to 8.72 nm. The addition of nanoparticles and MA improved wettability, tensile strength, and polymerization stability, while decreasing UV-B transmittance and surface roughness. Antibacterial activity against Staphylococcus aureus was also confirmed. Conclusion : It was verified that the addition of MA to cerium(IV)-zirconium(IV) oxide nanoparticles improved polymerization stability, tensile strength, and wettability. Therefore, these materials may be suitable for use in functional contact lenses for ophthalmic medical applications.

Abstract
Ⅰ. Introduction
Ⅱ. Materials and Methods
    1. Reagents and Materials
    2. Methods
Ⅲ. Results and Discussion
    1. Surface Analysis
    2. Spectral Transmittance
    3. Wettability and Tensile Strength
    4. Refractive Index and Water Content
    5. Polymerization Stability
    6. Antibacterial Activity
    7. Hydrogel Lenses Containing HydrophilicMonomers
Ⅳ. Conclusion
References
요 약

• Jin-Wook Kim(Dept. of Optometry and Vision Science, Daegu Catholic University, Student, Daegu) | 김진욱 (대구가톨릭대학교 대학원 안경광학과, 학생, 대구)
• A-Young Sung(Dept. of Optometry and Vision Science, Daegu Catholic University, Professor, Daegu) | 성아영 (대구가톨릭대학교 안경광학과, 교수, 대구) Corresponding author