A cold roll-bonding (CRB) process is applied to fabricate an AA1050/AA5052 layered sheet. In the process, commercial AA1050 and AA5052 sheets of 1 mm thickness, 40 mm width and 300 mm length are stacked onto each other, and then reduced to a thickness of 0.5 mm through a 2-pass cold rolling process without lubricant. The roll-bonded AA1050/AA5052 layered sheet is then annealed for 1 h at various temperatures from 200 to 400 °C. The specimens annealed at temperatures below 250 °C showed a typical deformation structure in which the grains were elongated along the rolling direction. However, the specimens annealed at temperatures higher than 300 °C exhibited recrystallization structures in both the AA1050 and AA5052 regions. All the roll-bonded and subsequently annealed specimens showed an inhomogeneous distribution of hardness in the thickness direction, in which the hardness in the AA5052 regions was higher than that in the AA1050 regions. As the annealing temperature increased, the tensile and yield strengths decreased and the elongation increased gradually. The mechanical properties were compared to those of commercial AA1050 and AA5052 materials and CRBed AA5052-2L materials from a previous study.