This study focuses on analyzing the impact range of toxicity, overpressure and radiant heat (pool fire and boiling liquid expanding vapor explosion, BLEVE) resulting from a propylene oxide leakage accident and proposes mitigation strategies to minimize damage. A risk assessment was conducted by designing accident scenarios based on variables such as substance quantity and wind speed. The results indicated that toxicity and BLEVE were the primary risk factors, and the risk level increased as the substance quantity increased and wind speed decreased. For future mitigation strategies, it is suggested that a quantitative analysis of vapor dispersion rates and dilution and effects under various environmental conditions be conducted, along with preliminary research on optimizing absorbents and catalytic materials.