This study compared the growth, yield characteristics, and nutrient absorption of two perilla cultivars (‘Ipdeulkkae 1’ and ‘Donggeul 2’) treated with various nutrient solution levels (EC 1.0, 1.2, 1.4, and 1.6 dS·m-1). The results showed that plant growth and yield significantly increased with higher EC levels, particularly for ‘Donggeul 2’ under EC 1.4 dS·m-1, which exhibited superior production and high nutrient use efficiency. These results indicate that increasing EC improves nutrient status, thereby enhancing photosynthetic efficiency and biomass production. Furthermore, ‘Ipdeulkkae 1’ showed excellent growth at higher EC levels, while ‘Donggeul 2’ responded more sensitively to changes in NH₄ concentration but maintained stable productivity at lower EC conditions. The findings suggest the need for tailored nutrient solution management strategies that consider cultivar-specific differences. While elevated EC levels positively influenced yield, they also confirmed that excessively high EC can cause osmotic stress and ion imbalance. This study provides essential data for determining optimal EC levels for high-quality and stable perilla production. Future research should examine the interactions between nutrient solution concentration and environmental factors to develop more precise nutrient management techniques and to facilitate select superior cultivars.